WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=64; E=13.73; R=4.66; rawP=1.76e-24; adjP=1.81e-22
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163864 NA NMNAT3 nicotinamide nucleotide adenylyltransferase 3 349565 ENSG00000163864
2  ENSG00000014919 NA COX15 COX15 homolog, cytochrome c oxidase assembly protein (yeast) 1355 ENSG00000014919
3  ENSG00000078070 NA MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 56922 ENSG00000078070
4  ENSG00000130707 NA ASS1 argininosuccinate synthase 1 445 ENSG00000130707
5  ENSG00000099998 NA GGT5 gamma-glutamyltransferase 5 2687 ENSG00000099998
6  ENSG00000006695 NA COX10 COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) 1352 ENSG00000006695
7  ENSG00000073578 NA SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 6389 ENSG00000073578
8  ENSG00000125166 NA GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 2806 ENSG00000125166
9  ENSG00000062485 NA CS citrate synthase 1431 ENSG00000062485
10  ENSG00000140740 NA UQCRC2 ubiquinol-cytochrome c reductase core protein II 7385 ENSG00000140740
11  ENSG00000094841 NA UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 139596 ENSG00000094841
12  ENSG00000091140 NA DLD dihydrolipoamide dehydrogenase 1738 ENSG00000091140
13  ENSG00000152127 NA MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 4249 ENSG00000152127
14  ENSG00000135587 NA SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 6610 ENSG00000135587
15  ENSG00000103356 NA EARS2 glutamyl-tRNA synthetase 2, mitochondrial (putative) 124454 ENSG00000103356
16  ENSG00000130313 NA PGLS 6-phosphogluconolactonase 25796 ENSG00000130313
17  ENSG00000167186 NA COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 10229 ENSG00000167186
18  ENSG00000122729 NA ACO1 aconitase 1, soluble 48 ENSG00000122729
19  ENSG00000156958 NA GALK2 galactokinase 2 2585 ENSG00000156958
20  ENSG00000119689 NA DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 1743 ENSG00000119689
21  ENSG00000110435 NA PDHX pyruvate dehydrogenase complex, component X 8050 ENSG00000110435
22  ENSG00000144591 NA GMPPA GDP-mannose pyrophosphorylase A 29926 ENSG00000144591
23  ENSG00000100412 NA ACO2 aconitase 2, mitochondrial 50 ENSG00000100412
24  ENSG00000112294 NA ALDH5A1 aldehyde dehydrogenase 5 family, member A1 7915 ENSG00000112294
25  ENSG00000239672 NA NME1 NME/NM23 nucleoside diphosphate kinase 1 4830 ENSG00000239672
26  ENSG00000112992 NA NNT nicotinamide nucleotide transhydrogenase 23530 ENSG00000112992
27  ENSG00000185883 NA ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 527 ENSG00000185883
28  ENSG00000033100 NA CHPF2 chondroitin polymerizing factor 2 54480 ENSG00000033100
29  ENSG00000184886 NA PIGW phosphatidylinositol glycan anchor biosynthesis, class W 284098 ENSG00000184886
30  ENSG00000023228 NA NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 4719 ENSG00000023228
31  ENSG00000119711 NA ALDH6A1 aldehyde dehydrogenase 6 family, member A1 4329 ENSG00000119711
32  ENSG00000113790 NA EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 1962 ENSG00000113790
33  ENSG00000146085 NA MUT methylmalonyl CoA mutase 4594 ENSG00000146085
34  ENSG00000143252 NA SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 6391 ENSG00000143252
35  ENSG00000149541 NA B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) 26229 ENSG00000149541
36  ENSG00000163931 NA TKT transketolase 7086 ENSG00000163931
37  ENSG00000198931 NA APRT adenine phosphoribosyltransferase 353 ENSG00000198931
38  ENSG00000110955 NA ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 506 ENSG00000110955
39  ENSG00000121578 NA B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 8702 ENSG00000121578
40  ENSG00000038274 NA MAT2B methionine adenosyltransferase II, beta 27430 ENSG00000038274
41  ENSG00000161267 NA BDH1 3-hydroxybutyrate dehydrogenase, type 1 622 ENSG00000161267
42  ENSG00000137992 NA DBT dihydrolipoamide branched chain transacylase E2 1629 ENSG00000137992
43  ENSG00000131844 NA MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 64087 ENSG00000131844
44  ENSG00000100714 NA MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 4522 ENSG00000100714
45  ENSG00000136143 NA SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 8803 ENSG00000136143
46  ENSG00000176022 NA B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 126792 ENSG00000176022
47  ENSG00000116337 NA AMPD2 adenosine monophosphate deaminase 2 271 ENSG00000116337
48  ENSG00000114054 NA PCCB propionyl CoA carboxylase, beta polypeptide 5096 ENSG00000114054
49  ENSG00000182050 NA MGAT4C mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) 25834 ENSG00000182050
50  ENSG00000137124 NA ALDH1B1 aldehyde dehydrogenase 1 family, member B1 219 ENSG00000137124
51  ENSG00000158089 NA GALNT14 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) 79623 ENSG00000158089
52  ENSG00000066926 NA FECH ferrochelatase 2235 ENSG00000066926
53  ENSG00000111012 NA CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1594 ENSG00000111012
54  ENSG00000196177 NA ACADSB acyl-CoA dehydrogenase, short/branched chain 36 ENSG00000196177
55  ENSG00000161533 NA ACOX1 acyl-CoA oxidase 1, palmitoyl 51 ENSG00000161533
56  ENSG00000171428 NA NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 9 ENSG00000171428
57  ENSG00000149380 NA P4HA3 prolyl 4-hydroxylase, alpha polypeptide III 283208 ENSG00000149380
58  ENSG00000075239 NA ACAT1 acetyl-CoA acetyltransferase 1 38 ENSG00000075239
59  ENSG00000114491 NA UMPS uridine monophosphate synthetase 7372 ENSG00000114491
60  ENSG00000152234 NA ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 498 ENSG00000152234
61  ENSG00000075651 NA PLD1 phospholipase D1, phosphatidylcholine-specific 5337 ENSG00000075651
62  ENSG00000156110 NA ADK adenosine kinase 132 ENSG00000156110
63  ENSG00000106049 NA HIBADH 3-hydroxyisobutyrate dehydrogenase 11112 ENSG00000106049
64  ENSG00000107242 NA PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 8395 ENSG00000107242


Database:KEGG pathway       Name:Valine, leucine and isoleucine degradation       ID:00280
C=44; O=12; E=0.53; R=22.45; rawP=1.35e-13; adjP=6.95e-12
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000114054 NA PCCB propionyl CoA carboxylase, beta polypeptide 5096 ENSG00000114054
2  ENSG00000196177 NA ACADSB acyl-CoA dehydrogenase, short/branched chain 36 ENSG00000196177
3  ENSG00000146085 NA MUT methylmalonyl CoA mutase 4594 ENSG00000146085
4  ENSG00000113790 NA EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 1962 ENSG00000113790
5  ENSG00000119711 NA ALDH6A1 aldehyde dehydrogenase 6 family, member A1 4329 ENSG00000119711
6  ENSG00000078070 NA MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 56922 ENSG00000078070
7  ENSG00000075239 NA ACAT1 acetyl-CoA acetyltransferase 1 38 ENSG00000075239
8  ENSG00000137124 NA ALDH1B1 aldehyde dehydrogenase 1 family, member B1 219 ENSG00000137124
9  ENSG00000091140 NA DLD dihydrolipoamide dehydrogenase 1738 ENSG00000091140
10  ENSG00000137992 NA DBT dihydrolipoamide branched chain transacylase E2 1629 ENSG00000137992
11  ENSG00000131844 NA MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 64087 ENSG00000131844
12  ENSG00000106049 NA HIBADH 3-hydroxyisobutyrate dehydrogenase 11112 ENSG00000106049


Database:KEGG pathway       Name:Citrate cycle (TCA cycle)       ID:00020
C=30; O=8; E=0.36; R=21.95; rawP=2.08e-09; adjP=7.14e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000136143 NA SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 8803 ENSG00000136143
2  ENSG00000100412 NA ACO2 aconitase 2, mitochondrial 50 ENSG00000100412
3  ENSG00000143252 NA SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 6391 ENSG00000143252
4  ENSG00000122729 NA ACO1 aconitase 1, soluble 48 ENSG00000122729
5  ENSG00000062485 NA CS citrate synthase 1431 ENSG00000062485
6  ENSG00000091140 NA DLD dihydrolipoamide dehydrogenase 1738 ENSG00000091140
7  ENSG00000119689 NA DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 1743 ENSG00000119689
8  ENSG00000073578 NA SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 6389 ENSG00000073578


Database:KEGG pathway       Name:Glyoxylate and dicarboxylate metabolism       ID:00630
C=18; O=6; E=0.22; R=27.43; rawP=5.13e-08; adjP=1.32e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000075239 NA ACAT1 acetyl-CoA acetyltransferase 1 38 ENSG00000075239
2  ENSG00000114054 NA PCCB propionyl CoA carboxylase, beta polypeptide 5096 ENSG00000114054
3  ENSG00000100412 NA ACO2 aconitase 2, mitochondrial 50 ENSG00000100412
4  ENSG00000146085 NA MUT methylmalonyl CoA mutase 4594 ENSG00000146085
5  ENSG00000122729 NA ACO1 aconitase 1, soluble 48 ENSG00000122729
6  ENSG00000062485 NA CS citrate synthase 1431 ENSG00000062485


Database:KEGG pathway       Name:Propanoate metabolism       ID:00640
C=32; O=7; E=0.39; R=18.00; rawP=9.72e-08; adjP=2.00e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000075239 NA ACAT1 acetyl-CoA acetyltransferase 1 38 ENSG00000075239
2  ENSG00000136143 NA SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 8803 ENSG00000136143
3  ENSG00000114054 NA PCCB propionyl CoA carboxylase, beta polypeptide 5096 ENSG00000114054
4  ENSG00000137124 NA ALDH1B1 aldehyde dehydrogenase 1 family, member B1 219 ENSG00000137124
5  ENSG00000146085 NA MUT methylmalonyl CoA mutase 4594 ENSG00000146085
6  ENSG00000113790 NA EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 1962 ENSG00000113790
7  ENSG00000119711 NA ALDH6A1 aldehyde dehydrogenase 6 family, member A1 4329 ENSG00000119711


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=11; E=1.64; R=6.71; rawP=8.86e-07; adjP=1.44e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000138641 NA HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 8916 ENSG00000138641
2  ENSG00000185345 NA PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 5071 ENSG00000185345
3  ENSG00000139842 NA CUL4A cullin 4A 8451 ENSG00000139842
4  ENSG00000185338 NA SOCS1 suppressor of cytokine signaling 1 8651 ENSG00000185338
5  ENSG00000003096 NA KLHL13 kelch-like 13 (Drosophila) 90293 ENSG00000003096
6  ENSG00000108094 NA CUL2 cullin 2 8453 ENSG00000108094
7  ENSG00000140464 NA PML promyelocytic leukemia 5371 ENSG00000140464
8  ENSG00000163743 NA RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 25898 ENSG00000163743
9  ENSG00000049759 NA NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 23327 ENSG00000049759
10  ENSG00000012048 NA BRCA1 breast cancer 1, early onset 672 ENSG00000012048
11  ENSG00000119401 NA TRIM32 tripartite motif containing 32 22954 ENSG00000119401


Database:KEGG pathway       Name:Lysine degradation       ID:00310
C=44; O=7; E=0.53; R=13.09; rawP=9.76e-07; adjP=1.44e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000075239 NA ACAT1 acetyl-CoA acetyltransferase 1 38 ENSG00000075239
2  ENSG00000137124 NA ALDH1B1 aldehyde dehydrogenase 1 family, member B1 219 ENSG00000137124
3  ENSG00000136169 NA SETDB2 SET domain, bifurcated 2 83852 ENSG00000136169
4  ENSG00000113790 NA EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 1962 ENSG00000113790
5  ENSG00000152952 NA PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 5352 ENSG00000152952
6  ENSG00000119689 NA DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 1743 ENSG00000119689
7  ENSG00000185973 NA TMLHE trimethyllysine hydroxylase, epsilon 55217 ENSG00000185973


Database:KEGG pathway       Name:Peroxisome       ID:04146
C=79; O=8; E=0.96; R=8.33; rawP=5.52e-06; adjP=7.11e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000213965 NA NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 390916 ENSG00000213965
2  ENSG00000162928 NA PEX13 peroxisomal biogenesis factor 13 5194 ENSG00000162928
3  ENSG00000173208 NA ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 225 ENSG00000173208
4  ENSG00000113790 NA EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 1962 ENSG00000113790
5  ENSG00000161533 NA ACOX1 acyl-CoA oxidase 1, palmitoyl 51 ENSG00000161533
6  ENSG00000100372 NA SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 10478 ENSG00000100372
7  ENSG00000127980 NA PEX1 peroxisomal biogenesis factor 1 5189 ENSG00000127980
8  ENSG00000203797 NA DDO D-aspartate oxidase 8528 ENSG00000203797


Database:KEGG pathway       Name:Fatty acid metabolism       ID:00071
C=43; O=6; E=0.52; R=11.48; rawP=1.30e-05; adjP=0.0001
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000075239 NA ACAT1 acetyl-CoA acetyltransferase 1 38 ENSG00000075239
2  ENSG00000196177 NA ACADSB acyl-CoA dehydrogenase, short/branched chain 36 ENSG00000196177
3  ENSG00000137124 NA ALDH1B1 aldehyde dehydrogenase 1 family, member B1 219 ENSG00000137124
4  ENSG00000113790 NA EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 1962 ENSG00000113790
5  ENSG00000161533 NA ACOX1 acyl-CoA oxidase 1, palmitoyl 51 ENSG00000161533
6  ENSG00000169169 NA CPT1C carnitine palmitoyltransferase 1C 126129 ENSG00000169169


Database:KEGG pathway       Name:Oxidative phosphorylation       ID:00190
C=132; O=9; E=1.60; R=5.61; rawP=3.65e-05; adjP=0.0004
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000014919 NA COX15 COX15 homolog, cytochrome c oxidase assembly protein (yeast) 1355 ENSG00000014919
2  ENSG00000023228 NA NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 4719 ENSG00000023228
3  ENSG00000143252 NA SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 6391 ENSG00000143252
4  ENSG00000140740 NA UQCRC2 ubiquinol-cytochrome c reductase core protein II 7385 ENSG00000140740
5  ENSG00000185883 NA ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 527 ENSG00000185883
6  ENSG00000110955 NA ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 506 ENSG00000110955
7  ENSG00000152234 NA ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 498 ENSG00000152234
8  ENSG00000006695 NA COX10 COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) 1352 ENSG00000006695
9  ENSG00000073578 NA SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 6389 ENSG00000073578




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).